| Protocol No. | Title | Status |
| 05-0013-04 | A COG Soft Tissue Biology and Banking Protocol | Open |
| 05-0014-04 | Vincristine, Dactinomycin, and Lower Doses of Cyclophosphamide with or without Radiation Therapy for Patients with Newly Diagnosed Low-Risk Embryonal/Botryoid/Spindle Cell Rhabdomyosarcoma | Open |
| 05-0509-04 | LABORATORY STUDIES OF SOFT TISSUE SARCOMAS (formerly HSCA0535) | Open |
| 07-0062-10 | Randomized Study of Vincristine, Dactinomycin and Cyclophosphamide (VAC) versus VAC Alternating with Vincristine and Irinotecan (VI) for Patients with Intermediate-Risk Rhabdomyosarcoma (RMS) | Open |
| 07-0632-10 | Risk-Based Treatment for Pediatric Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS) | Open |
| 20110545 | A Randomized Controlled Study of YONDELIS(Trabectedin) or Dacarbazine for the Treatment of Advanced Liposarcoma or Leiomyosarcoma | Open |
| 20110924 | A Randomized, Open-label, Multicenter, Phase 3 Study to Compare the Efficacy and Safety of Eribulin with Dacarbazine in Subjects with Soft Tissue Sarcoma | Open |
| 20111252 | A Randomized Phase 3, Multicenter, Open-Label Study Comparing TH-302 in Combination with Doxorubicin vs. Doxorubicin Alone in Subjects with Locally Advanced Unresectable or Metastatic Soft Tissue Sarcoma | Open |